Journal: Scientific Reports
Article Title: Temporal ablation of the ciliary protein IFT88 alters normal brainwave patterns
doi: 10.1038/s41598-024-83432-1
Figure Lengend Snippet: Inducible IFT88 KO mice have reduced EEG power over a broad spectrum. ( a. ) Power spectrum density plots (PSDs) of EEG waveform power broken down by frequency ranges reveals a shift in brainwave activity. Delta = 1 – 4 Hz, Theta = 4 – 8 Hz, Alpha = 8 – 13 Hz, Beta = 13 – 30 Hz, Gamma = 30 – 50 Hz. ( b. ) Cumulative distribution plots of the above PSDs show a shift in EEG waveform to a lower power. Overall EEG waveform activity was reduced in inducible IFT88 KOs in both the wake (p = 0.017) and non-REM (p = 0.034) states (Kolmogorov–Smirnov test).
Article Snippet: To characterize if IFT88 KO mice share this pathology the 24-h EEG/EMG recordings were filtered to remove the DC offset as well as line current and then further processed in MATLAB to generate power spectrum density plots (PSDs; Fig. ).
Techniques: Activity Assay